Skin penetration by indomethacin is enhanced by use of an indomethacin/smectite complex

The effect of indomethacin/smectite complex on skin penetration enhancement of indomethacin in cataplasm has been examined. Complexation with smectite increases the stability of amorphous indomethacin resulting in a complex that is more skin-permeable than the free drug. Complexation of indomethacin...

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Published inJournal of supramolecular chemistry Vol. 1; no. 4; pp. 217 - 219
Main Authors Ito, Taketoshi, Sugafuji, Toshihiro, Maruyama, Miyuki, Ohwa, Yutaka, Takahashi, Toshio
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.07.2001
Subjects
Complex
Indomethacin
Skin penetration
Smectite
Skin penetration
Indomethacin
Smectite
Complex
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Summary:The effect of indomethacin/smectite complex on skin penetration enhancement of indomethacin in cataplasm has been examined. Complexation with smectite increases the stability of amorphous indomethacin resulting in a complex that is more skin-permeable than the free drug. Complexation of indomethacin with smectite increases the stability of amorphous indomethacin in a complex that is more skin-permeable than the free drug.
ISSN:1472-7862
DOI:10.1016/S1472-7862(02)00028-X