Experimental photodynamic therapy: 15 years of development

• Published in: Russian journal of general chemistry Vol. 85; no. 1; pp. 217 - 239
• Main Authors: Yakubovskaya, R. I., Morozova, N. B., Pankratov, A. A., Kazachkina, N. I., Plyutinskaya, A. D., Karmakova, T. A., Andreeva, T. N., Venediktova, Yu. B., Plotnikova, E. A., Nemtsova, E. R., Sokolov, V. V., Filonenko, E. V., Chissov, V. I., Kogan, B. Ya, Butenin, A. V., Feofanov, A. V., Strakhovskaya, M. G.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2015
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal); Phthalocyanine; Photodynamic Therapy; Radiation Energy Density; Radiation Power Density; General Chemistry
• ISSN: 1070-3632; 1608-3350
• DOI: 10.1134/S1070363215010405

Photodynamic therapy and fluorescence diagnosis of malignant tumors have been actively developed over the last 15 years by the scientists participating in the Moscow Government-funded “Fight against Cancer” program. New effective photosensitizers absorbing in the long-wave spectral region were revealed. Unique agents Alasens-lio, Alasens-gel, Hexasens-lio, Phthalosens-lio, Holosens-lio, and Holosensgel were produced and preclinically studied both in vitro and in vivo . New methods using low-intensity and pulse modes of irradiation and also combined methods of treatment by photodynamic therapy and well-known chemotherapy or laser hyperthermia were developed. Methodological recommendations for experimental studies of agents with photoinduced antitumor properties were published.