The impact of haematoxylin-eosin staining and immunohistochemistry of lentigo maligna and lentigo maligna melanoma margins on local recurrence

• Published in: EJD. European journal of dermatology Vol. 32; no. 6; pp. 750 - 755
• Main Authors: Eckardt, Julia, Behrens, Victoria, Kofler, Katrin, Forchhammer, Stephan, Häfner, Hans-Martin, Kofler, Lukas
• Format: Journal Article
• Language: English
• Published: Paris John Libbey Eurotext 01.11.2022
• Subjects: Dermatology; Eosine Yellowish-(YS); Humans; Hutchinson's Melanotic Freckle; Immunohistochemistry; Investigative Report; Medicine; Medicine & Public Health; Retrospective Studies; Skin Neoplasms; Staining and Labeling; lentigo maligna; immunohistochemistry; lentigo maligna melanoma; micrographic-controlled surgery; local recurrences
• ISSN: 1167-1122; 1952-4013
• DOI: 10.1684/ejd.2022.4379

Background Local recurrence of lentigo maligna melanoma (LMM) and lentigo maligna (LM) continue to be challenging following surgical treatment and aftercare. Objectives To investigate haematoxylin-eosin staining and immunohistochemistry of the tumour margins of LM and LMM and evaluate the impact of these data on local recurrence. Materials & Methods In total, 489 tumours were included in this retrospective single-centre study, among them 199 (40.7%) LMs and 290 (59.3%) LMMs. All tumours were excised using micrographic-controlled surgery. Additional immunohistochemistry staining of the tumour margins was performed in 35 specimens (7.2%). Results Based on haematoxylin-eosin staining alone, 82/454 tumours (18.1%) were shown to develop local recurrence compared to 3/35 tumours (8.6%) when additional immunohistochemistry was performed. Conclusion Following micrographic-controlled surgery, the additional use of immunohistochemistry of tumour margins of LM/LMM reduced the risk of local recurrence, although this was not statistically significant.