The increase in aneuploidy of embryos Is associated with pathological morphology of the sperm

Chromosomes of embryos of couples with reduced number of morphologically normal sperm cells (less than 4%) and couples with a normal level of morphologically normal sperm cells (over 4%) has revealed significant differences. In the group with a low level of normal spermatozoa, the frequency of embry...

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Published inRussian journal of genetics Vol. 53; no. 12; pp. 1378 - 1381
Main Authors Kiseleva, Yu. Yu, Azova, M. M., Kodyleva, T. A., Kirillova, A. O., Ekimov, A. N., Rakitko, A. S., Mishieva, N. G., Abubakirov, A. N.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2017
Subjects
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Short Communications
aneuploidy
sperm morphology
genetic screening
IСSI
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Summary:Chromosomes of embryos of couples with reduced number of morphologically normal sperm cells (less than 4%) and couples with a normal level of morphologically normal sperm cells (over 4%) has revealed significant differences. In the group with a low level of normal spermatozoa, the frequency of embryos with normal chromosomes is significantly reduced and incidence of sex chromosome trisomies and autosomal monosomies and trisomies is increased; a tendency to decrease has been found for the frequency of male embryos. The obtained data may be useful to establish additional criteria for preimplantation genetic screening in the case of male infertility.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795417120055