OXIDATIVE DEMETHYLATION OF 4-SUBSTITUTED N,N-DIMETHYLANILINES WITH IODINE AND CALCIUM-OXIDE IN THE PRESENCE OF METHANOL

Reaction of para-substituted N,N-dimethylarylamines with iodine-calcium oxide in tetrahydrofuran-methanol affords N-methylarylamines in good yield.

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Bibliographic Details
Published inJournal of the Chemical Society. Chemical communications no. 17; pp. 1985 - 1986
Main Authors ACOSTA, K, CESSAC, JW, RAO, PN, KIM, HK
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 1994
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Exact sciences and technology
Organic chemistry
Physical Sciences
Science & Technology
SYSTEM
TERTIARY-AMINES
OXYGEN ATOM TRANSFER
DEALKYLATION
MODEL
CYTOCHROME-P-450
DRUG-METABOLISM
Demethylation
Organic solvent
Binary compound
Calcium oxide
Tertiary amine
Benzenic compound
Aromatic compound
Oxidation
Experimental study
Secondary amine
Iodine
Methanol
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Summary:Reaction of para-substituted N,N-dimethylarylamines with iodine-calcium oxide in tetrahydrofuran-methanol affords N-methylarylamines in good yield.
ISSN:0022-4936
DOI:10.1039/c39940001985