Comparative Study of Polycomplexes Based on Carbopol® and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System

We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol ® polym...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 49; no. 1; pp. 1 - 6
Main Authors Mustafin, R. I., Semina, I. I., Garipova, V. R., Bukhovets, A. V., Sitenkov, A. Yu, Salakhova, A. R., Gennari, C. G. M., Cilurzo, F.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2015
Subjects
Medicine
Molecular Biology Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Carbopol
chitosan
EPO
intestinal release
release of model drugs
bioadhesion
pharmacokinetic studies
interpolyelectrolyte complex
Eudragit
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Summary:We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol ® polymer (C71g, C2020) and Noveon ® AA-1 and oppositely charged polyelectrolytes – Eudragit ® EPO or the natural polysaccharide low-viscosity chitosan. These studies demonstrated the potential for IPEC samples based on Carbopol ® as a new modified-release drug delivery system. At the same time, assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1211-2