Synthesis of macrocycles on the basis of diterpenoid isosteviol and trehalose

Macrocyclic glycoterpenoids containing trehalose and isosteviol fragments have been synthesized. Selective screening has revealed compounds exhibiting antitubercular activity against H37RV, M. Avium and M. Terrae at a level comparable to the known antitubercular drugs isoniazid, ofloxacin, and pyraz...

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Published inRussian journal of organic chemistry Vol. 51; no. 10; pp. 1488 - 1498
Main Authors Garifullin, B. F., Sharipova, R. R., Strobykina, I. Yu, Andreeva, O. V., Kravchenko, M. A., Kataev, V. E.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2015
Springer Nature
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Organic Chemistry
Physical Sciences
Science & Technology
Antitubercular Activity
Steviol
Isosteviol
Trehalose
Macrocycle
CHEMISTRY
ACID
RECEPTORS
DERIVATIVES
WATER
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Summary:Macrocyclic glycoterpenoids containing trehalose and isosteviol fragments have been synthesized. Selective screening has revealed compounds exhibiting antitubercular activity against H37RV, M. Avium and M. Terrae at a level comparable to the known antitubercular drugs isoniazid, ofloxacin, and pyrazinamide.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428015100231