A green four-component synthesis of 2-amino-3-cyano-4-aryl-6-sulfanepyrimidine in water solvent using phase-transfer catalyst

New green one-pot four-component reactions of thiourea, malononitrile halohydrocarbon, aldehydes and alkyl halide have been successfully developed in eco-friendly water solvent through available phase-transfer catalyst, to access high yields of 2-amino-3-cyano-4-aryl-6-sulfanepyrimidines.

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Bibliographic Details
Published inJournal of the Iranian Chemical Society Vol. 13; no. 4; pp. 597 - 604
Main Authors Xu, Liang, Gu, Chenghao, Li, Rou, Yu, Yikai, Wang, Tao
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2016
Subjects
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Pyrimidine derivatives
Multicomponent reactions
Knoevenagel reaction
Water solvent
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Summary:New green one-pot four-component reactions of thiourea, malononitrile halohydrocarbon, aldehydes and alkyl halide have been successfully developed in eco-friendly water solvent through available phase-transfer catalyst, to access high yields of 2-amino-3-cyano-4-aryl-6-sulfanepyrimidines.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-015-0770-1