Simple synthesis of new chiral oxindole derivative

A synthesis of chiral optically active 3-hydroxyoxindoles with 1,3-disubstituted 2,2-dimethyl-cyclobutane structural fragment by the Et 2 NH-catalyzed aldol reaction of indoline-2,3-diones with (−)-(1 S ,3 S )-pinonic acid derivatives is described.

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Bibliographic Details
Published inRussian chemical bulletin Vol. 57; no. 7; pp. 1571 - 1574
Main Authors Makaev, F. Z., Radul, O. M., Gudima, A. P.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.07.2008
Subjects
Brief Communications
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
oxindoles
isatin
pinonic acid derivatives
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Summary:A synthesis of chiral optically active 3-hydroxyoxindoles with 1,3-disubstituted 2,2-dimethyl-cyclobutane structural fragment by the Et 2 NH-catalyzed aldol reaction of indoline-2,3-diones with (−)-(1 S ,3 S )-pinonic acid derivatives is described.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-008-0204-7