Synthesis of 2-(arylamino)nicotinic acids in high-temperature water

In hydrothermal reactions at 150–180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up...

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Published inResearch on chemical intermediates Vol. 38; no. 7; pp. 1691 - 1697
Main Authors Li, Zhenghua, Xiao, Shangyou, Liang, Ronghui, Xia, Zhining
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.09.2012
Subjects
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
High-temperature water
2-(Arylamino)nicotinic acids
2-Chloronicotinic acid
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Summary:In hydrothermal reactions at 150–180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%).
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-012-0494-0