Synthesis of 2-(arylamino)nicotinic acids in high-temperature water
In hydrothermal reactions at 150–180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up...
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Published in | Research on chemical intermediates Vol. 38; no. 7; pp. 1691 - 1697 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer Netherlands
01.09.2012
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Subjects | |
Online Access | Get full text |
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Summary: | In hydrothermal reactions at 150–180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%). |
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ISSN: | 0922-6168 1568-5675 |
DOI: | 10.1007/s11164-012-0494-0 |