Triclosan-loaded with high encapsulation efficiency into PLA nanoparticles coated with β-cyclodextrin polymer

• Published in: Journal of Inclusion Phenomena and Macrocyclic Chemistry Vol. 75; no. 3-4; pp. 277 - 283
• Main Authors: El Fagui, Amani, Dubot, Pierre, Loftsson, Thorsteinn, Amiel, Catherine
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2013
• Subjects: Chemistry; Chemistry and Materials Science; Crystallography and Scattering Methods; Food Science; Organic Chemistry; Original Article; Nanoparticles; Bovine serum albumin; β-Cyclodextrin polymer; Triclosan; PLA
• ISSN: 0923-0750; 1573-1111
• DOI: 10.1007/s10847-012-0128-6

The purpose was to prepare triclosan-loaded polylactic acid nanoparticles containing β-cyclodextrin polymer shell, evaluate triclosan release from the particles using Franz diffusion cells and to study the stability of the particles in presence of a model protein, bovine serum albumin. The nanoparticles were prepared by a solvent displacement process. The nanoparticles were characterized by their size, encapsulation efficiency and morphology. They were of spherical shape with hydrodynamic diameter of about 100 or 200 nm depending on the polylactic acid used. Their high encapsulation efficiency (~90%) indicated that triclosan is easily incorporated into the nanoparticles. The nanoparticles displayed slow and sustained triclosan release patterns (diffusion coefficient about 10 −22  m 2 /s) and the β-cyclodextrin polymer coating was stable under simulated physiological conditions. All these data indicated that these novel core–shell nanoparticles might provide a promising carrier system for controlled release of triclosan and other hydrophobic drugs after systemic administration.