Association of catalase (rs7943316) and glutathione peroxidase-1 (rs1050450) polymorphisms with the risk of type 2 diabetes (T2DM)
Reactive oxygen species are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Catalase and Glutathione peroxidase-1 are antioxidant enzymes and the activity of them is essential for the protection against damage caused by reactive oxygen species. The aim of this study was to investiga...
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Published in | Molecular genetics, microbiology and virology Vol. 30; no. 4; pp. 216 - 220 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Allerton Press
01.10.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Reactive oxygen species are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Catalase and Glutathione peroxidase-1 are antioxidant enzymes and the activity of them is essential for the protection against damage caused by reactive oxygen species. The aim of this study was to investigate the association between genetic polymorphisms of
CAT
gene (rs7943316) and
GPx-1
gene (rs1050450) in patients with type 2 diabetes. In this case-control study, a total of 120 Iranian patients with T2DM and 120 healthy individuals as control were included. Genotypes were determined by PCR-RFLP. A significant difference was found between genotyping distribution of
CAT
(–21 A/T) polymorphism.The frequency of TT genotype was increased in patients compared to controls and we observed a statistically significant difference (
OR
= 1.797, 95%
CI
= 0.975–3.318,
P
= 0.044). Distribution of genotypes did not differ for
GPx-1
(198 C/T) polymorphism between the cases and controls subjects. This study indicated that
CAT
rs7943316 genotype (TT) was associated with an increased risk of T2DM. No evidence was found to support an association between
GPx-1
(198 C/T) polymorphism and T2DM. |
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ISSN: | 0891-4168 1934-841X |
DOI: | 10.3103/S0891416815040096 |