Induction of Apoptosis in Bone Marrow Cells is Mediated via Purinergic Receptors

ATP activity in mouse bone marrow cells was in vitro estimated by expression of phosphatidylserine on the outer membrane surface using FITC-labeled annexin. ATP induced apoptosis in bone marrow cells. Purinergic receptor antagonists PPADS and suramin modulated the apoptotic effect of ATP on hemopoie...

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Published inBulletin of experimental biology and medicine Vol. 138; no. 2; pp. 116 - 118
Main Authors Uspenskaya, Yu. A., Mikhutkina, S. V., Taksanova, E. I., Popova, N. N., Olovyannikova, R. Ya, Salmina, A. B.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.08.2004
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Summary:ATP activity in mouse bone marrow cells was in vitro estimated by expression of phosphatidylserine on the outer membrane surface using FITC-labeled annexin. ATP induced apoptosis in bone marrow cells. Purinergic receptor antagonists PPADS and suramin modulated the apoptotic effect of ATP on hemopoietic cells. Acute and subacute administration of doxorubicin, an inductor of oxidative burst, decreased cell sensitivity to ATP and abolished its apoptotic effect.
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000048365.80201.fc