Efficacy of Amikacin in Septic Abortion: Serum and Urine Antibiotic Concentrations

Septic abortion is a frequent cause of maternal death in our patient population. The great majority of bacteria isolated were enterobacteria. Since antibiotics capable of destroying the cell wall release endotoxins (producing vasoconstriction and tissue hypoxia) antibiotics which do not destroy bact...

Full description

Saved in:
Bibliographic Details
Published inJournal of international medical research Vol. 4; no. 4; pp. 223 - 227
Main Authors Bravo-Sandoval, Jorge, Cinco-Espinoza, Gonzalo, Ramírez-López, Donato, Becerra-Muñoz, Enrique, Galindo-Hernández, Emma, Flores-Mercado, Francisco
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.1976
Subjects
Abortion, Septic - therapy
Adolescent
Adult
Amikacin - administration & dosage
Amikacin - metabolism
Amikacin - therapeutic use
Curettage
Escherichia coli Infections - drug therapy
Female
Humans
Kanamycin - analogs & derivatives
Pregnancy
Online AccessGet full text

Cover

More Information
Summary:Septic abortion is a frequent cause of maternal death in our patient population. The great majority of bacteria isolated were enterobacteria. Since antibiotics capable of destroying the cell wall release endotoxins (producing vasoconstriction and tissue hypoxia) antibiotics which do not destroy bacteria like amikacin are preferred. Amikacin, 500 mg intramuscularly every twelve hours, was used concomitantly with uterine curettage and fluid and electrolyte restoration in thirty septic abortion patients. All the patients responded, obviating the need for more heroic surgical treatment such as hysterectomy. Previously used antibiotics have not been as effective in our patient population.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0300-0605
1473-2300
DOI:10.1177/030006057600400402