Synthesis of lipid mediators based on 1,2-dialkylglycerol and cholesterol for targeted delivery of oligo- and polynucleotides into hepatocytes

The synthesis of cationic glycolipids containing galactose or lactose residue as hepatocyte-targeted markers is described.

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Bibliographic Details
Published inRussian chemical bulletin Vol. 59; no. 1; pp. 251 - 259
Main Authors Morozova, N. G., Maslov, M. A., Petukhova, O. A., Andronova, S. V., Grishaeva, A. O., Serebrennikova, G. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 2010
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
dialkylglycerol
lipofection
cationic lipids
Key words
cholesterol
galactose
lactose
hepatocytes
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Summary:The synthesis of cationic glycolipids containing galactose or lactose residue as hepatocyte-targeted markers is described.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-010-0070-y