Synthesis of biologically active compounds and biopharmaceutical aspects of polymorphic and solvatomorphic modifications

The design of new highly efficient drugs for the treatment of various diseases is an important problem and a top-priority task in medicinal chemistry in most countries of the world. Therefore, the synthesis of biologically active compounds and modifications of known medications are being actively in...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 63; no. 5; pp. 1057 - 1067
Main Authors Skachilova, S. Ya, Shilova, E. V., Mitrokhin, N. M.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2014
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Reviews
synthesis
biological activity
crystal modifications
drugs
solvatomorphism
pharmacological study
polymorphism
computer-aided chemistry
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Summary:The design of new highly efficient drugs for the treatment of various diseases is an important problem and a top-priority task in medicinal chemistry in most countries of the world. Therefore, the synthesis of biologically active compounds and modifications of known medications are being actively investigated. The solution of these problems involves the following two main lines: (1) computer-assisted studies of structure—activity relationships, computer-based modeling of new structures, targeted synthesis; (2) studies of the influence of crystal, polymorphic, and solvatomorphic modifications on biological and pharmacological properties. The review deals with the data on new biologically active compounds and drugs of such pharmacotherapeutic groups as cardiovascular, antiasthmatic, and antiallergic.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-014-0549-z