Synthesis of 1-(2-aminoethyl)pyrazoles under phase-transfer catalysis

Alkylation of pyrazoles with 2-chloroethylamine was performed under conditions of phasetransfer catalysis. Depending on the substrate acidity, the electrophilic substitution process may be accompanied by dehydrochlorination of the alkylating agent, so that 6 equiv of 2-chloroethylamine should be use...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 78; no. 1; pp. 136 - 138
Main Authors Attaryan, O. S., Baltayan, A. O., Sagatelyan, R. E., Takmazyan, K. Ts
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 2008
Springer Nature
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Physical Sciences
Science & Technology
Ethylammonium
General Chemistry
Isomer Mixture
Pyrazole
Methylpyrazole
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Summary:Alkylation of pyrazoles with 2-chloroethylamine was performed under conditions of phasetransfer catalysis. Depending on the substrate acidity, the electrophilic substitution process may be accompanied by dehydrochlorination of the alkylating agent, so that 6 equiv of 2-chloroethylamine should be used in the alkylation of 3,5-dimethylpyrazole.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363208010234