Role of Gene-Gene Interactions in the Chromosomal Instability in Workers at Coal Thermal Power Plants

• Published in: Russian journal of genetics Vol. 54; no. 1; pp. 91 - 102
• Main Authors: Savchenko, Ya. A., Minina, V. I., Bakanova, M. L., Ryzhkova, A. V., Soboleva, O. A., Kulemin, Yu. E., Voronina, E. N., Glushkov, A. N., Vafin, I. A.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2018
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Human Genetics; Medical Genetics; Microbial Genetics and Genomics; genes of antioxidant system enzymes; xenobiotics biotransformation genes; DNA repair genes; biomarkers; DNA methylation genes; chromosomal aberrations; gene-gene interaction; thermal power plants
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795418010106

The 23 polymorphic variants in genes encoding the enzymes of xenobiotics biotransformation (CYP1A1 (rs4646903), CYP1A2 (rs762551), GSTP1 (rs1138272, rs1695), GSTM1 (del) , and GSTT1 ( del )), DNA repair ( XRCC1 ( rs25489, rs25487 ), APEX1 (rs1130409), hOGG1 (rs1052133), ADPRT (rs1136410), XPD (rs13181), XPG (rs17655), XPC (rs2228001), ATM (rs1801516), NBS (rs1805794), XRCC2 (rs3218536) , and XRCC3 ( rs861539 )), antioxidant system ( MnSOD (rs4880 ) and GPx1 ( rs1050450 )), cell cycle control and apoptosis ( TP53 ( rs1042522 )), DNA methylation ( MTHFR (rs1801133 ) and MTR ( rs1805087 )), and chromosomal aberrations in lymphocytes in the workers at thermal power plants were analyzed. We found that allelic variants in the CYP1A1 (rs4646903), hOGG1 (rs1052133), XRCC1 (rs25487) , and APEX1 ( rs1130409 ) genes were associated with an increased level of chromosomal aberrations in workers. Informative models of gene-gene interactions including CYP1A1 ( rs4646903 , T > C ), CYP1A2 ( rs762551 , C > A ), GSTT1 (del); XRCC1 ( rs25487 , G > A ), MTHFR ( rs1801133 , C > T ), GSTT1 (del) ; XRCC1 ( rs25487 , G > A ), APEX1 ( rs1130409 , T > G ), TP53 ( rs1042522 , G > C ) determining the formation of the increased frequency of chromosomal aberrations in the workers at coal thermal power plants were discovered.