Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

• Published in: Russian journal of general chemistry Vol. 85; no. 1; pp. 280 - 288
• Main Authors: Meerovich, I. G., Sanarova, E. V., Meerovich, G. A., Derkacheva, V. M., Volkov, K. A., Negrimovsky, V. M., Barkanova, S. V., Lukyanets, E. A., Oborotova, N. A., Smirnova, Z. S., Borisova, L. M., Lantsova, A. V., Polozkova, A. P., Orlova, O. L., Loschenov, V. B., Umnova, L. V., Baryshnikov, A. Yu, Vorozhtsov, G. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2015
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal); Lewis Lung Carcinoma; Phthalocyanine; Liposomal Form; Photodynamic Therapy; General Chemistry
• ISSN: 1070-3632; 1608-3350
• DOI: 10.1134/S1070363215010430

The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710–740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.