Budd-Chiari Syndrome and antithrombin III deficiency

Presented herein is a case report of a 20-year-old woman with a past history of oral contraceptive use who developed Budd-Chiari syndrome. Onset of her illness was abrupt and stormy, simulating fulminant viral hepatitis or toxic hepatic injury. She died within six months of her initial presentation....

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Bibliographic Details
Published inAmerican journal of clinical pathology Vol. 78; no. 2; pp. 236 - 241
Main Authors McClure, S, Dincsoy, H P, Glueck, H
Format Journal Article
LanguageEnglish
Published England 01.08.1982
Subjects
Adult
Antithrombin III Deficiency
Budd-Chiari Syndrome - complications
Budd-Chiari Syndrome - pathology
Contraceptives, Oral - adverse effects
Female
Humans
Kidney - pathology
Liver - pathology
Vena Cava, Inferior - pathology
Americas
Hemic System
Age Factors
Contraceptive Agents
United States
Biology
Research Methodology
North America
Ethnic Groups
Vascular Diseases
Population Characteristics
Population
Blood Coagulation Effects
Physiology
Hepatic Effects
Thromboembolism
Demographic Factors
Contraceptive Agents, Female
Mortality
Oral Contraceptives > side effects
Reproductive Control Agents
Contraception
Contraceptive Methods > side effects
Family Planning
Thrombosis
Embolism
Diseases
Studies
Northern America
Developed Countries
Treatment
Hematological Effects
Case Studies
Ohio
Population Dynamics
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Summary:Presented herein is a case report of a 20-year-old woman with a past history of oral contraceptive use who developed Budd-Chiari syndrome. Onset of her illness was abrupt and stormy, simulating fulminant viral hepatitis or toxic hepatic injury. She died within six months of her initial presentation. Although the patient discontinued the use of oral contraceptives two years prior to the initial presentation of the disease, the morphologic features of the venous thrombosis and hepatic damage were indicative of a chronic, ongoing process of longer than six months' duration, thus raising the possibility of a cause-effect relationship between the "pills" and thrombotic process. Of interest was the finding of persistently depressed antithrombin III levels. While a relationship between oral contraceptive usage, antithrombin III deficiency and the Budd-Chiari syndrome is strongly suggested in this case, prospective studies are needed to substantiate this view.
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/78.2.236