The influence of removing passenger cells on the fate of skin and parathyroid allografts. Evidence for major histocompatibility complex restriction in transplantation immunity

Studies with mice on the survival of skin grafts incompatible with respect to the histocompatibiiity-Y transplantation antigen or to skin-specific antigens, as well as studies with rats on the fate of cultured parathyroid allografts, provide evidence for major histocompatibility restriction in trans...

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Published inDiabetes (New York, N.Y.) Vol. 31 Suppl 4; no. Supplement_4; pp. 60 - 62
Main Authors Silvers, W K, Fleming, H L, Naji, A, Barker, C F
Format Journal Article
LanguageEnglish
Published United States 01.08.1982
Subjects
Animals
Female
Graft Survival
Immune Tolerance
Islets of Langerhans - immunology
Islets of Langerhans Transplantation
Leukocytes - immunology
Major Histocompatibility Complex
Mice
Mice, Inbred C57BL
Parathyroid Glands - immunology
Parathyroid Glands - transplantation
Skin - immunology
Skin Transplantation
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Summary:Studies with mice on the survival of skin grafts incompatible with respect to the histocompatibiiity-Y transplantation antigen or to skin-specific antigens, as well as studies with rats on the fate of cultured parathyroid allografts, provide evidence for major histocompatibility restriction in transplantation immunity. If confirmed, these studies indicate that islet allografts devoid of passenger leukocytes might survive better in major histocompatibility complex incompatible recipients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0012-1797
1939-327X
DOI:10.2337/diab.31.4.s60