A Study of alkylation regioselectivity of 5-substituted tetrazoles with chloroacetamides

Alkylation of 5-aryltetrazoles with N -arylchloroacetamides commonly proceeds regioselectively at 2 position of the tetrazole ring. The ratio of 1,5- and 2,5-regioisomers depends on the nature of a substituents in the benzene ring of the N -arylchloroacetamide and position of a substituent in the ar...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 80; no. 4; pp. 836 - 841
Main Authors Pokhodylo, N. T., Savka, R. D., Matiichuk, V. S., Obushak, N. D.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.04.2010
Springer Nature
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Physical Sciences
Science & Technology
Chloroacetanilide
General Chemistry
Tetrazole Ring
Alkylation
Chloroacetamide
GAS-PHASE
ACID
SERIES
TAUTOMERIC EQUILIBRIUM
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Summary:Alkylation of 5-aryltetrazoles with N -arylchloroacetamides commonly proceeds regioselectively at 2 position of the tetrazole ring. The ratio of 1,5- and 2,5-regioisomers depends on the nature of a substituents in the benzene ring of the N -arylchloroacetamide and position of a substituent in the aryltetrazole aryl group. Features of 1 H NMR spectra of the synthesized compounds are discussed.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363210040262