Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings
Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower...
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| Published in | Neurology Vol. 31; no. 9; p. 1142 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.09.1981
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower in siblings sharing no haplotypes with the case. Within case-sibling pairs, the presence of HLA-A-A3 and/or B7 affected measles antibody titers more than the presence of MS. These findings suggest that the immune response to measles in these sibships is influenced by the presence of HLA-A-A3 and/or B7 as well as another familial factor. |
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| AbstractList | Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower in siblings sharing no haplotypes with the case. Within case-sibling pairs, the presence of HLA-A-A3 and/or B7 affected measles antibody titers more than the presence of MS. These findings suggest that the immune response to measles in these sibships is influenced by the presence of HLA-A-A3 and/or B7 as well as another familial factor. |
| Author | Detels, R Sever, J L Sullivan, C B Terasaki, P I Madden, D L Dudley, J P Visscher, B R Park, M S |
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| Snippet | Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no... |
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| SubjectTerms | Adult Antibodies, Viral - analysis Cytomegalovirus - immunology Female Haploidy Herpesviridae - immunology Histocompatibility HLA Antigens - analysis Humans Male Measles virus - immunology Multiple Sclerosis - genetics Multiple Sclerosis - immunology |
| Title | Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings |
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