Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings

Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower...

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Bibliographic Details
Published inNeurology Vol. 31; no. 9; p. 1142
Main Authors Visscher, B R, Sullivan, C B, Detels, R, Madden, D L, Sever, J L, Terasaki, P I, Park, M S, Dudley, J P
Format Journal Article
LanguageEnglish
Published United States 01.09.1981
Subjects
Adult
Antibodies, Viral - analysis
Cytomegalovirus - immunology
Female
Haploidy
Herpesviridae - immunology
Histocompatibility
HLA Antigens - analysis
Humans
Male
Measles virus - immunology
Multiple Sclerosis - genetics
Multiple Sclerosis - immunology
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Summary:Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower in siblings sharing no haplotypes with the case. Within case-sibling pairs, the presence of HLA-A-A3 and/or B7 affected measles antibody titers more than the presence of MS. These findings suggest that the immune response to measles in these sibships is influenced by the presence of HLA-A-A3 and/or B7 as well as another familial factor.
ISSN:0028-3878
DOI:10.1212/wnl.31.9.1142