Molecular Markers of Chemotherapy Toxicity in Colorectal Cancer

Personalized medicine appears to be the inevitable consequence of improvements in our understanding of the mechanisms of action of chemotherapeutic agents, as well as the description of the human genome and its impact on our understanding of the genes involved in DNA repair and drug metabolism. Thes...

Full description

Saved in:
Bibliographic Details
Published inCurrent colorectal cancer reports Vol. 7; no. 1; pp. 105 - 111
Main Authors Braun, Michael S., Seymour, Matthew T.
Format Journal Article
LanguageEnglish
Published New York Current Science Inc 01.03.2011
Subjects
Colorectal Surgery
Medicine
Medicine & Public Health
Oncology
Proctology
Irinotecan
Oxaliplatin
Colorectal
Toxicity
Fluorouracil
Pharmacogenomics
Online AccessGet full text

Cover

More Information
Summary:Personalized medicine appears to be the inevitable consequence of improvements in our understanding of the mechanisms of action of chemotherapeutic agents, as well as the description of the human genome and its impact on our understanding of the genes involved in DNA repair and drug metabolism. These rapid developments have been associated with the first efforts to establish genetic predictors of chemotherapy efficacy and toxicity for the chemotherapy drugs active in colorectal cancer—fluorouracil, irinotecan, and oxaliplatin.
ISSN:1556-3790
1556-3804
DOI:10.1007/s11888-010-0078-6