Photogenerator of trichloroacetic acid as a promising detritylation agent for oligonucleotide microarray synthesis

[[4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl]-2,2,2-trichloroacetate, which generates trichloroacetic acid when irradiated with light of 405 nm wavelength, has been studied as a detritylation agent in the oligonucleotide microarray synthesis. This agent was shown to be suitable for the de...

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Bibliographic Details
Published inRussian journal of bioorganic chemistry Vol. 40; no. 5; pp. 586 - 588
Main Authors Sinyakov, A. N., Nikolaenkova, E. B., Os’kina, I. A., Savel’ev, V. A., Samsonov, V. A., Tikhonov, A. Y., Palatkina, M. Yu, Zaytsev, D. E.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2014
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
oligodeoxyribonucleotides
trityl cation
photogenerated acids
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Summary:[[4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl]-2,2,2-trichloroacetate, which generates trichloroacetic acid when irradiated with light of 405 nm wavelength, has been studied as a detritylation agent in the oligonucleotide microarray synthesis. This agent was shown to be suitable for the deprotection of the 4,4′-dimethoxytrityl group during the solid phase oligonucleotide synthesis.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162014050124