Relationship between the aggregation of nanoparticles bearing zinc ions and cytotoxicity and morphology of blood cells

The effect of nanoparticles bearing magnetic and nonmagnetic zinc nuclei on lymphocytes from healthy donors and leukemic cells of patients (15–20 years old) with acute B-lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML) was considered. The studies by confocal and fluorescence microscop...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 62; no. 4; pp. 1120 - 1124
Main Authors Orlova, M. A., Osipova, E. Yu, Rumiantsev, S. A., Zaitsev, D. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.04.2013
Subjects
Brief Communications
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
apoptosis
zinc-67
aggregation
nanoparticles
magnetic isotope effect
pophyrinfullerene
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Summary:The effect of nanoparticles bearing magnetic and nonmagnetic zinc nuclei on lymphocytes from healthy donors and leukemic cells of patients (15–20 years old) with acute B-lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML) was considered. The studies by confocal and fluorescence microscopy showed an apoptotic effect of nanoparticles bearing zinc ions. An increase in the aggregation of the nanoparticles and cell self-aggregation, resulting in a decrease in cytotoxicity, were observed in the case of the magnetic isotope. In spite of this, cell apoptosis under the action of even aggregated nanoparticles bearing magnetic 67 Zn was significantly higher than the apoptosis with lymphocytes of healthy donors and with nanoparticles bearing zinc of the total isotope composition.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-013-0152-8