Granulomatous Gastritis and Natural Infection with Spirilla in Beagle Dogs
Since granulomatous gastritis and infection with spirilla were observed in most of the Beagle dogs sacrificed for a certain toxicity study, we investigated the stomach histopathologically. The lesions were characterized by degeneration and erosion in the mucosal and crypt epithelium, diffuse and foc...
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Published in | Journal of Toxicologic Pathology Vol. 11; no. 1; p. 69 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Tokyo
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
1998
Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | Since granulomatous gastritis and infection with spirilla were observed in most of the Beagle dogs sacrificed for a certain toxicity study, we investigated the stomach histopathologically. The lesions were characterized by degeneration and erosion in the mucosal and crypt epithelium, diffuse and focal infiltration of inflammatory cells containing foreign body giant cells in the lamina propria and hyperplasia of lymphoid follicles in the submucosa. Spirilla were adhered to the epithelium and seen in the crypt lacunae without invading into the tissues. However, they invaded into the cytoplasm of the parietal cells and induced mild degeneration and necrosis. The granulomatous lesions and spirilla were more markedly observed in the pylorus than in the fundus. There was no clear relationship between granuloma and spirilla, but granulomas were considered to be formed by foreign materials invading from the gastric lumen through the destroyed epithelium. |
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ISSN: | 0914-9198 1881-915X 1347-7404 |
DOI: | 10.1293/tox.11.69 |