Synthesis and Biological Evaluation of a Novel Series of Pyrazolylcoumarins as Anti-Inflammatory and Antioxidant Agents
Abstract A new series of pyrazolylcoumarins ( 4a-k ) was synthesized by reaction of appropriate dibromochalcones ( 3a-k ) with phenyl hydrazine in ethanol. Structures of all new synthesized compounds were characterized on the basis of elemental analysis and spectral data (UV, IR and 1 H NMR). The ti...
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Published in | Drug research (Stuttgart) Vol. 63; no. 1; pp. 28 - 33 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Stuttgart · New York
Georg Thieme Verlag KG
01.01.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract
A new series of pyrazolylcoumarins (
4a-k
) was synthesized by reaction of appropriate dibromochalcones (
3a-k
) with phenyl hydrazine in ethanol. Structures of all new synthesized compounds were characterized on the basis of elemental analysis and spectral data (UV, IR and
1
H NMR). The title compounds were screened for
in vivo
anti-inflammatory activities at a dose of 200 mg/kg b.w. Among the 11 prepared compounds, Compounds
4c, d, h
and
i
exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compound
4d
showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis along with minimum ulcerogenic index and were compared with diclofenac (13.5 mg/kg b.w.) as a standard drug. Additionally, the synthesized compounds were evaluated for their in vitro antioxidant activity. Compound
4k
was found to be the most active antioxidant in the series compared with standard vitamin C. |
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ISSN: | 2194-9379 2194-9387 |
DOI: | 10.1055/s-0032-1331225 |