Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS

Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee. The animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms. Central nervous system lesions were pr...

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Bibliographic Details
Published inAnnals of neurology Vol. 5; no. 1; p. 89
Main Authors Rorke, L B, Iwasaki, Y, Koprowski, H, Wroblewska, Z, Gilden, D H, Warren, K G, Lief, F S, Hoffman, S, Cummins, L B, Rodriguez, A R, Kalter, S S
Format Journal Article
LanguageEnglish
Published United States 01.01.1979
Subjects
Animals
Demyelinating Diseases - etiology
Demyelinating Diseases - pathology
Female
Humans
Microscopy, Electron
Middle Aged
Multiple Sclerosis - etiology
Pan troglodytes
Spinal Cord - pathology
Spinal Cord - ultrastructure
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Summary:Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee. The animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms. Central nervous system lesions were primarily localized in the spinal cord at root entry zones; these were characterized by demyelination and regeneration of myelin by Schwann cells.
ISSN:0364-5134
DOI:10.1002/ana.410050113