The synthesis of poly(lactide)-vitamin E TPGS (PLA-TPGS) copolymer and its utilization to formulate a curcumin nanocarrier

Abstract Curcumin is a natural substance that exhibits the ability to inhibit and / or treat carcinogenesis in a variety of cell lines, but because of its poor solubility in water the treatment efficacy is limited. In this paper we report on the fabrication of self-assembled micelle nanoparticles lo...

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Published inAdvances in natural sciences. Nanoscience and nanotechnology Vol. 1; no. 1; p. 015012
Main Authors Thu Ha, Phuong, Nguyet Tran, Thi Minh, Pham, Hong Duong, Nguyen, Quang Huan, Nguyen, Xuan Phuc
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.03.2010
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Summary:Abstract Curcumin is a natural substance that exhibits the ability to inhibit and / or treat carcinogenesis in a variety of cell lines, but because of its poor solubility in water the treatment efficacy is limited. In this paper we report on the fabrication of self-assembled micelle nanoparticles loaded with a curcumin drug by use of a biocompatible copolymer of PLA-TPGS (d-a-tocopheryl polyethylene glycol 1000 succinate—vitamin E TPGS) conjugate. The polylactide (PLA)-TPGS copolymer synthesized by ring-opening polymerization was characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) techniques. The surface morphology of PLA-TPGS and curcumin loaded PLA-TPGS was determined by field emission scanning electron microscopy (FE-SEM). The absorption and fluorescence examinations indicated that due to micellar capsulation the intensity of both types of spectra increased by about 4 times in comparison with those of the free curcumin sample.
ISSN:2043-6262
2043-6262
DOI:10.1088/2043-6254/1/1/015012