Axon selection From a polarized cytoplasm to a migrating neuron

The shape of a neuron supplies valuable clues as to its function. Neurons typically extend a single long, thin axon, which will transmit signals, and several shorter and thicker dendrites, which will receive signals. The understanding of the means by which neurons acquire a polarized morphology is a...

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Bibliographic Details
Published inCommunicative & integrative biology Vol. 4; no. 3; pp. 304 - 307
Main Authors Calderon de Anda, Froylan, Tsai, Li-Huei
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.05.2011
Landes Bioscience
Subjects
Addendum
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
cortex development
neuronal polarity
centrosome
cytoskeleton
Axon selection
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Summary:The shape of a neuron supplies valuable clues as to its function. Neurons typically extend a single long, thin axon, which will transmit signals, and several shorter and thicker dendrites, which will receive signals. The understanding of the means by which neurons acquire a polarized morphology is a fundamental issue in developmental neurobiology. The current view suggests that axon selection involves a stochastic mechanism. However, new data suggest that a polarized cytoplasm not only determines the position of neurite emergence, but also sets the conditions for morphological polarization. In vertebrates, neurons migrate before establishing their final morphology. Recent work shows that the polarized cytoplasm also determines how neurons migrate. Thus, neuronal migration might influence the processes by which neurons form an axon. 
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ISSN:1942-0889
1942-0889
DOI:10.4161/cib.4.3.14781