Facile preparation of amine and amino acid adducts of [60]fullerene using chlorofullerene C60Cl6 as a precursor

• Published in: Chemical communications (Cambridge, England) Vol. 48; no. 44; pp. 5461 - 5463
• Main Authors: Kornev, Alexey B, Khakina, Ekaterina A, Troyanov, Sergey I, Kushch, Alla A, Peregudov, Alexander, Vasilchenko, Alexey, Deryabin, Dmitry G, Martynenko, Vyacheslav M, Troshin, Pavel A
• Format: Journal Article
• Language: English
• Published: England 04.06.2012
• Subjects: Amines - chemistry; Amino Acids - chemistry; Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antiviral Agents - chemical synthesis; Antiviral Agents - pharmacology; Bacillus subtilis - drug effects; Bacillus subtilis - growth & development; Cations; Cercopithecus aethiops; Crystallography, X-Ray; Cytomegalovirus - drug effects; Cytomegalovirus - physiology; Escherichia coli - drug effects; Escherichia coli - growth & development; Fibroblasts - drug effects; Fibroblasts - virology; Fullerenes - chemistry; Humans; Injections, Intraperitoneal; Lethal Dose 50; Magnetic Resonance Spectroscopy; Mice; Simplexvirus - drug effects; Simplexvirus - physiology; Vero Cells - drug effects; Vero Cells - virology
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c2cc00071g

We report a general synthetic approach to the preparation of highly functionalized amine and amino acid derivatives of [60]fullerene starting from readily available chlorofullerene C(60)Cl(6). The synthesized water-soluble amino acid derivative of C(60) demonstrated pronounced antiviral activity, while the cationic amine-based compound showed strong antibacterial action in vitro.