Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements;...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 66; pp. 8219 - 8221
Main Authors Braga, Dario, Grepioni, Fabrizia, Maini, Lucia, Capucci, Davide, Nanna, Saverio, Wouters, Johan, Aerts, Luc, Quéré, Luc
Format Journal Article
LanguageEnglish
Published England 25.08.2012
Subjects
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Crystallization
Ions
Lithium - chemistry
Models, Molecular
Neuroprotective Agents - chemistry
Piracetam - chemistry
Temperature
X-Ray Diffraction
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Summary:Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33855f