Genetic mapping and ENU mutagenesis

ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplo...

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Bibliographic Details
Published inGenetica Vol. 122; no. 1; pp. 65 - 69
Main Authors Beier, David R, Herron, Bruce J
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.09.2004
Subjects
Animals
Chromosome Mapping
Ethylnitrosourea
Female
Genetic Markers
Haplotypes
Male
Mice
Mutagenesis
Mutation
Pedigree
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Summary:ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplotype analysis can facilitate this with even small numbers of affected progeny.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0016-6707
1573-6857
DOI:10.1007/s10709-004-1437-5