Peculiarities of Neurohormonal Modulation of Memory and Learning Processes in Young and Old Monkeys Macaca mulatta

• Published in: Journal of evolutionary biochemistry and physiology Vol. 41; no. 6; pp. 677 - 688
• Main Author: Sollertinskaya, T N
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.11.2005
• Subjects: Adrenocorticotropic hormone; Animal cognition; Cortex; Data processing; Hormones; Hypothalamus; Immunohistochemistry; Intranasal administration; Learning; Macaca mulatta; Memory; Monkeys & apes; Neurology; Neuromodulation; Neurotransmitters; Reflexes; Vasopressin
• ISSN: 0022-0930; 1608-3202
• DOI: 10.1007/s10893-006-0010-5

Comparative data are presented about peculiarities of neurohormonal regulation of the memory and learning processes in young and old monkeys Macaca mulatta. It is shown that the hypothalamic neurohormones, vasopressin and thyroliberine, produce on the whole a unidirectional facilitating effect on the inherited and simple forms of the nervous activity in young and old animals. It is established that vasopressin, thyroliberine, and ACTH sub(4-10) participate differently in regulation and compensation of disturbed higher nervous functions in old monkeys. The compensatory effects of vasopressin are more pronounced at intranasal administration of its ultrasmall (0.01 jg/kg) doses. The thyroliberine administration had the longer and more expressed disinhibition effect on the conditional reflex memory in old monkeys, as compared with young ones. The question is discussed about different effects of vasopressin and thyroliberine on the higher nervous functions in young and old monkeys from the point of view of cytoarchitectonic changes in the neocortex and of immunohistochemical changes in the hypothalamus nuclear structures.