Palladium-catalyzed direct phosphonation of azoles with dialkyl phosphites

The first Pd-catalyzed direct phosphonation of azoles with dialkyl phosphites has been achieved without addition of base or acid. This method involves the oxidative cleavage of C-H and P(O)-H bonds and represents an atom-efficiency alternative to the classical phosphonation of Ar-X. A Pd-II/Pd-IV me...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 42; pp. 5181 - 5183
Main Authors Hou, Chaodong, Ren, Yunlai, Lang, Rui, Hu, Xiaoxue, Xia, Chungu, Li, Fuwei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 25.05.2012
Subjects
Azoles - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Oxidation-Reduction
Palladium - chemistry
Phosphites - chemistry
Physical Sciences
Science & Technology
HALIDES
CROSS-COUPLING REACTIONS
DIRECT AMINATION
MECHANISM
ARYL
ALKYNES
C-H BONDS
ARYLBORONIC ACIDS
DIRECT ALKYLATION
Online AccessGet full text

Cover

More Information
Summary:The first Pd-catalyzed direct phosphonation of azoles with dialkyl phosphites has been achieved without addition of base or acid. This method involves the oxidative cleavage of C-H and P(O)-H bonds and represents an atom-efficiency alternative to the classical phosphonation of Ar-X. A Pd-II/Pd-IV mechanism has been studied and proposed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30429e