Malvidin and its Glycosides from Vaccinium ashei Improve Endothelial Function by Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory Effects

Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-α, and inhibit monocyte chemotacti...

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Bibliographic Details
Published inNatural product communications Vol. 13; no. 1
Main Authors Huang, Wu-Yang, Wang, Xing-Na, Wang, Jing, Sui, Zhong-Quan
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2018
Subjects
Malvidin and glycosides
Blueberry
Anti-inflammation
ACE inhibitor
Endothelial cells
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Summary:Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-α, and inhibit monocyte chemotactic protein-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of IκBα and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF-κB pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801300115