Copper-catalyzed decarboxylative C3-acylation of free (N-H) indoles with alpha-oxocarboxylic acids

An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using alpha-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 12; no. 11; pp. 1721 - 1724
Main Authors Wang, Cuiping, Wang, Shaoyan, Li, Hua, Yan, Jingbo, Chi, Haijun, Chen, Xichao, Zhang, Zhiqiang
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.03.2014
Subjects
Acylation
Carboxylic Acids - chemistry
Catalysis
Chemistry
Chemistry, Organic
Copper - chemistry
Indoles - chemistry
Physical Sciences
Science & Technology
FRIEDEL-CRAFTS ACYLATION
ROOM-TEMPERATURE
ARYLATION
BIARYL SYNTHESIS
BOND ACTIVATION
PYRROLES
DERIVATIVES
C-H
BENZOIC-ACIDS
CARBOXYLIC-ACIDS
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Summary:An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using alpha-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high
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ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob42171f