Electroplated porous polypyrrole nanostructures patterned by colloidal lithography for drug-delivery applications

Porous nanostructures of polypyrrole (Ppy) were fabricated using colloidal lithography and electrochemical techniques for potential applications in drug delivery. A sequential fabrication method was developed and optimized to maximize the coverage of the Ppy nanostructures and to obtain a homogeneou...

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Bibliographic Details
Published inNanoscale Vol. 4; no. 10; p. 3083
Main Authors Pokki, J, Ergeneman, O, Sivaraman, K M, Ozkale, B, Zeeshan, M A, Lühmann, T, Nelson, B J, Pané, S
Format Journal Article
LanguageEnglish
Published England 21.05.2012
Subjects
Adsorption
Colloids - chemistry
Drug Carriers - chemistry
Nanostructures - chemistry
Polymers - chemistry
Polystyrenes - chemistry
Porosity
Pyrroles - chemistry
Rhodamines - chemistry
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Summary:Porous nanostructures of polypyrrole (Ppy) were fabricated using colloidal lithography and electrochemical techniques for potential applications in drug delivery. A sequential fabrication method was developed and optimized to maximize the coverage of the Ppy nanostructures and to obtain a homogeneous layer over the substrate. This was realized by masking with electrophoretically-assembled polystyrene (PS) nanospheres and then electroplating. Drug/biomolecule adsorption and the release characteristics for the porous nanostructures of Ppy were investigated using rhodamine B (Rh-B). Rh-B is an easily detectable small hydrophobic molecule that is used as a model for many drugs or biological substances. The porous Ppy nanostructures with an enhanced surface area exhibited higher Rh-B loading capacity than bulk planar films of Ppy. Moreover, tunability of surface morphology for further applications (e.g., sensing, cell adhesion) was demonstrated.
ISSN:2040-3364
2040-3372
DOI:10.1039/c2nr30192j