In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strai...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 45; pp. 5674 - 5676
Main Authors Matthes, Diana, Richter, Lennart, Mueller, Jane, Denisiuk, Alexander, Feifel, Sven C., Xu, Yuquan, Espinosa-Artiles, Patricia, Suessmuth, Roderich D., Molnar, Istvan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.06.2012
Subjects
Beauveria - chemistry
Beauveria - enzymology
Beauveria - genetics
Biocatalysis
Chemistry
Chemistry, Multidisciplinary
Cloning, Molecular
Depsipeptides - chemistry
Depsipeptides - metabolism
Escherichia coli - genetics
Mutation
Peptide Synthases - genetics
Peptide Synthases - metabolism
Physical Sciences
Science & Technology
PRECURSOR-DIRECTED BIOSYNTHESIS
ANTIBIOTICS
BASSIANA
DEPSIPEPTIDE BEAUVERICIN
ENNIATIN SYNTHETASE
POLYKETIDE SYNTHASE
FUSARIUM-OXYSPORUM
GENERATION
INHIBITORS
MUTASYNTHESIS
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Summary:New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.
Bibliography:National Science Foundation
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ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31669b