A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies

A bola-phospholipid probe, carrying a tetrafluorophenylazido chromophore in the middle of the transmembrane diacyl chain, was synthesized and characterized with a view to studying biomembranes by a photolabeling approach. This probe shows the advantageous stability of bola-lipids in giant vesicle fo...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 11; no. 30; pp. 5000 - 5005
Main Authors Xia, Yi, Sengupta, Kheya, Maggiani, Alain, Qu, Fanqi, Peng, Ling
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.08.2013
Subjects
Azides - chemistry
Chemistry
Chemistry, Organic
Fluorescent Dyes - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Membrane Proteins - analysis
Membrane Proteins - chemistry
Molecular Structure
Phospholipids - analysis
Phospholipids - chemistry
Photochemical Processes
Physical Sciences
Science & Technology
DESIGN
GLYCOPHORIN-A
VESICLES
MEMBRANE
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Summary:A bola-phospholipid probe, carrying a tetrafluorophenylazido chromophore in the middle of the transmembrane diacyl chain, was synthesized and characterized with a view to studying biomembranes by a photolabeling approach. This probe shows the advantageous stability of bola-lipids in giant vesicle formation alongside excellent photochemical properties conferred by the tetrafluorophenylazido chromophore, and thus constitutes a promising probe for biomembrane photolabeling studies.
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ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob40659h