Tomographic optical breast imaging guided by three-dimensional mammography

We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spa...

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Bibliographic Details
Published inApplied optics (2004) Vol. 42; no. 25; p. 5181
Main Authors Li, Ang, Miller, Eric L, Kilmer, Misha E, Brukilacchio, Thomas J, Chaves, Tina, Stott, Jonathan, Zhang, Quan, Wu, Tao, Chorlton, MaryAnn, Moore, Richard H, Kopans, Daniel B, Boas, David A
Format Journal Article
LanguageEnglish
Published United States 01.09.2003
Subjects
Breast
Computer Simulation
Female
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Mammography
Models, Theoretical
Optics and Photonics
Tomography
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Summary:We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.
ISSN:1559-128X
DOI:10.1364/AO.42.005181