Advances in urinary proteome analysis and applications in systems biology

The urinary proteome is the focus of many studies due to the ease of urine collection and the relative proteome stability. Systems biology allows the combination of multiple omics studies, forming a link between proteomics, metabolomics, genomics and transcriptomics. In-depth data interpretation is...

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Bibliographic Details
Published inBioanalysis Vol. 6; no. 19; pp. 2549 - 2569
Main Authors Filip, Szymon, Zoidakis, Jerome, Vlahou, Antonia, Mischak, Harald
Format Journal Article
LanguageEnglish
Published England 01.01.2014
Subjects
Biomarkers - urine
Humans
Metabolomics
Proteome - analysis
Proteomics - methods
Systems Biology - methods
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Summary:The urinary proteome is the focus of many studies due to the ease of urine collection and the relative proteome stability. Systems biology allows the combination of multiple omics studies, forming a link between proteomics, metabolomics, genomics and transcriptomics. In-depth data interpretation is achieved by bioinformatics analysis of -omics data sets. It is expected that the contribution of systems biology to the study of the urinary proteome will offer novel insights. The main focus of this review is on technical aspects of proteomics studies, available tools for systems biology analysis and the application of urinary proteomics in clinical studies and systems biology.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio.14.210