Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei

Burkholderia pseudomallei and mallei are biological agents of military significance. There has been significant research in recent years to develop medical countermeasures for these organisms. This review summarizes work which details aspects of the pathogenesis of B. pseudomallei and mallei and dis...

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Bibliographic Details
Published inMilitary medicine Vol. 174; no. 6; pp. 647 - 651
Main Authors Larsen, Joseph C, Johnson, Nathan H
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.06.2009
Subjects
Aerosols
Animals
Antibiotics
Bacterial Capsules - genetics
Bacterial Proteins - secretion
Bioterrorism
Burkholderia mallei
Burkholderia mallei - genetics
Burkholderia mallei - pathogenicity
Burkholderia pseudomallei
Burkholderia pseudomallei - genetics
Burkholderia pseudomallei - pathogenicity
Drug resistance
Equidae
FDA approval
Genome, Bacterial
Genomes
Genomics
Glanders - drug therapy
Glanders - microbiology
Glanders - transmission
Humans
Infections
Melioidosis - drug therapy
Melioidosis - microbiology
Melioidosis - transmission
Pathogenesis
Quorum Sensing
Sepsis
Virulence
World War II
Union of Soviet Socialist Republics > USSR
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Summary:Burkholderia pseudomallei and mallei are biological agents of military significance. There has been significant research in recent years to develop medical countermeasures for these organisms. This review summarizes work which details aspects of the pathogenesis of B. pseudomallei and mallei and discusses key scientific questions and directions for future research.
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ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED-D-03-0808