Lasiodiplactone A, a novel lactone from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1

Lasiodiplactone A ( 1 ), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 was established by analysis of NMR spectroscopic data and electronic circular dichroism (ECD) spectra. Lasiodiplactone A ( 1 ) was the first example...

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Published inOrganic & biomolecular chemistry Vol. 15; no. 30; pp. 6338 - 6341
Main Authors Chen, Senhua, Liu, Zhaoming, Liu, Hongju, Long, Yuhua, Chen, Dongni, Lu, Yongjun, She, Zhigang
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 02.08.2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
METABOLITES
CHEMICAL DIVERSITY
SESTERTERPENOIDS
BIOSYNTHESIS
INHIBITOR
XYLARIA SP
DISCOVERY
ALKALOIDS
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Summary:Lasiodiplactone A ( 1 ), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 was established by analysis of NMR spectroscopic data and electronic circular dichroism (ECD) spectra. Lasiodiplactone A ( 1 ) was the first example of lactone that possesses a unique tetracyclic system (12/6/6/5) of RAL 12 (12-membered β-resorcylic acid lactone) with a pyran ring and a furan ring. A possible biogenetic pathway for 1 was proposed. Compound 1 showed anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide activated in RAW264.7 cells with IC 50 value of 23.5 μM and exhibited potential α-glucosidase inhibitory activity with IC 50 values of 29.4 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/C7OB01657C