A ratiometric naphthalimide sensor for live cell imaging of copper(I)

A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu+ was synthesised. Copper recognition properties in solution were evaluated using H-1 NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of t...

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Published inChemical communications (Cambridge, England) Vol. 49; no. 49; pp. 5565 - 5567
Main Authors Satriano, Cristina, Sfrazzetto, Giuseppe Trusso, Amato, Maria Emanuela, Ballistreri, Francesco P., Copani, Agata, Giuffrida, Maria Laura, Grasso, Giuseppe, Pappalardo, Andrea, Rizzarelli, Enrico, Tomaselli, Gaetano A., Toscano, Rosa Maria
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.06.2013
Subjects
Cell Line, Tumor
Chemistry
Chemistry, Multidisciplinary
Copper - analysis
Humans
Microscopy, Confocal
Molecular Structure
Naphthalimides - chemical synthesis
Naphthalimides - chemistry
Neurons - chemistry
Neurons - pathology
Physical Sciences
Science & Technology
SELECTIVE FLUORESCENT SENSOR
STRATEGY
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Summary:A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu+ was synthesised. Copper recognition properties in solution were evaluated using H-1 NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc42069h