Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold bett...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 93; pp. 16710 - 16713
Main Authors Misra, S K, Wang, X, Srivastava, I, Imgruet, M K, Graff, R W, Ohoka, A, Kampert, T L, Gao, H, Pan, D
Format Journal Article
LanguageEnglish
Published England 01.01.2015
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
DNA Topoisomerases, Type II - metabolism
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Nanoparticles - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Polymers - pharmacology
STAT3 Transcription Factor - antagonists & inhibitors
STAT3 Transcription Factor - metabolism
Structure-Activity Relationship
Triple Negative Breast Neoplasms - drug therapy
Triple Negative Breast Neoplasms - metabolism
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Summary:We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc07709e