Can first trimester pregnancy-associated plasma protein-A predict the surfactant needs of preterm neonates?

• Published in: Journal of neonatal-perinatal medicine Vol. 15; no. 1; pp. 123 - 128
• Main Authors: Yakistiran, B, Karsli, M F, Canpolat, F E
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2022
• Subjects: Biomarkers; Female; Humans; Infant, Newborn; Infant, Premature; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Surface-Active Agents; respiratory distress syndrome; IGF-1; pregnancy associated plasma protein a; surfactant
• ISSN: 1934-5798; 1878-4429
• DOI: 10.3233/NPM-200560

Low values of pregnancy associated plasma protein A (PAPP-A), have been shown to be associated with some poor gestational outcomes, especially those related to placental deficiency such as pre-eclampsia and fetal growth restriction as well as preterm labor. The aim of this study was to compare first trimester PAPP-A MoM values with the surfactant needs of newborns of pregnant women who had a preterm delivery. This study included 216 pregnant women who had a preterm delivery, who were found to be in the low-risk group based on their aneuploidy screening. The women were separated into two groups based on the surfactant receipts of their newborns. A record was made of the obstetric history, birth characteristics of the preterm infants, and whether or not there was a need for surfactant. A comparison of the PAPP-A values of the two groups revealed that the group that received surfactant had statistically significantly lower PAPP-A values (t(-3.97) = 0.203, p < 0.001). When the cut-off value of PAPP-A was taken as 1 MoM and the gestational age was analyzed together with the birth weight, PAPP-A alone was found to be a significant independent variable for the prediction of respiratory distress syndrome (RDS) (p = 0.031; OR:8.2 (1.2-55.6)). The result of this study demonstrated that PAPP-A MoM values may be significant in predicting the need for surfactant in RDS, which is a frequently seen condition in the neonatal period.