Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells

Piceatannol, isolated from the roots of Rheum undulatum, prevented oxygen radical formation and inhibited lipid peroxidation; the effective concentrations were 25 μM for a radical scavenging assay and 2.1 μM for a microsome assay. Using cDNA microarray analysis to determine which genes were modulate...

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Published inBiotechnology letters Vol. 24; no. 6; pp. 463 - 467
Main Authors JEOUNG, Dooil, OH, Seong-Jun, LEES, Seongeun, BAEK, Myungin, LEE, Youn-Hyung, BAEK, Nam-In, KIM, Hae-Yeong
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.03.2002
Springer Nature B.V
Subjects
Biological and medical sciences
Biotechnology
Cancer
DNA microarrays
Fundamental and applied biological sciences. Psychology
Gene expression
oxygen radicals
Peroxidation
piceatannol
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Summary:Piceatannol, isolated from the roots of Rheum undulatum, prevented oxygen radical formation and inhibited lipid peroxidation; the effective concentrations were 25 μM for a radical scavenging assay and 2.1 μM for a microsome assay. Using cDNA microarray analysis to determine which genes were modulated by piceatannol, 33 genes were up-regulated while 157 genes were down-regulated in the human gastric cancer cell line.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1014517515785